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Interferon-Gamma (IFN ɣ): Definition & Importance

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a human cytokine. It is produced by macrophages, mast cells and fibroblasts, T cells, endothelial cells, and natural killer cells. When released into the bloodstream it acts as a monocyte colony-stimulating factor to produce white blood cells in the bone marrow (granulocytes, macrophages and eosinophils). It stimulates the production of lymphokines which regulate cellular immunity.

What is gm csf: Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) is a glycoprotein cytokine synthesized primarily by monocytes, but also by lymphocytes, mast cells, fibroblasts and other myeloid cells. GM-CSF acts as an endogenous pyrogen in humans and stimulates different types of cells with various activities including: chemotaxis, activation of macrophages, eosinophils, B lymphocytes and natural killer cells. It also plays a key role in the early phase of B cell differentiation stage.

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a monomeric glycoprotein that acts as a cytokine in humans. Macrophages, mast cells, T cells, endothelial cells, fibroblasts, and natural killer cells, secrete GM-CSF. Although the release of human GM-CSF is local, it can act in a paracrine fashion to recruit circulating monocytes, lymphocytes, and neutrophils to enhance host defense mechanisms. Like colony-stimulating factor 3 that specializes in the proliferation and maturation of neutrophils, GM-CSF stimulates a spectrum of cell types, especially eosinophils and macrophages. Through soluble mediators like histamine and cysteinyl leukotrienes (also termed leukotriene D4), it may activate mast cells to release inflammatory chemicals that cause swelling and pain.

Interferon gamma assay test, is a human dimerized soluble protein encoded by the IFNG gene. The biologically active IFN γ is an interlocking anti-parallel form of two monomers. IFN γ is the sole member of the type II IFN group. IFN γ binds to the IFN-γ receptor complex to elicit a cellular signal. Two subunits, IFNGR1 and IFNGR2, make up the IFN-γ receptor complex. Interferon gamma plays a crucial role in innate and adaptive immunity.

The Interferon Gamma Assay is a type of enzyme immunoassay to detect the presence of Interferon Gamma (IFNγ). IFN γ is the sole member of the type II IFN group. IFN γ binds to the IFN-γ receptor complex to elicit a cellular signal. Two subunits, IFNGR1 and IFNGR2, make up the IFN-γ receptor complex.

Existing therapies for the treatment of HIV-associated neurocognitive disorders involve interferon treatment of patients. Lately, several vaccines and peptide mimetics have also been developed to prevent HIV infections. Several clinical trials are currently underway in people with HIV-associated Alzheimer’s disease (AD). These investigations are evaluating three different types of drugs: TasPep®, entecavir, and IL-2, which are being actively used to prevent opportunistic infections such as tuberculosis, pneumonia, and cystitis caused by Mycobacterium avium complex and Mycoplasma pneumoniae bacteria. Revimmune® has already received FDA approval for the treatment of Grace–Lessing syndrome (GLS), an orphan disease that affects one in 15 million newborn babies worldwide. Interferon gamma activity is reported several times daily on this website: “Interferon Gamma is a natural intracellular protein that plays a key role in regulating cell proliferation, programmed cell death and immunity. This protein interferes with viral replication and decreases cellular self-reactivity (cellular immunity). Interferon gamma is also implicated in the process of retrovirus infection (viral resistance) from human to human.

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